canine aortic endothelial cells Search Results


canine aortic endothelial cells  (Cell Applications Inc)
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Cell Applications Inc canine aortic endothelial cells
FC5 binding to canine, rat and human <t>endothelial</t> cells. Binding studies were carried out as described in Methods section. Bar graph represents data from two independent studies and expressed as mean and range. CnAOEC: Canine (dog) aortic endothelial cells; SvRBEC: rat brain endothelial cells; hCMEC/D3: human brain endothelial cells. MFI: Mean Fluorescence Intensity. Since the objective of this experiment was simply to demonstrate cross-reactivity of FC5 with canine endothelial cells as a prerequisite for PK studies, binding across the three cell types was not compared statistically.
Canine Aortic Endothelial Cells, supplied by Cell Applications Inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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FC5 binding to canine, rat and human endothelial cells. Binding studies were carried out as described in Methods section. Bar graph represents data from two independent studies and expressed as mean and range. CnAOEC: Canine (dog) aortic endothelial cells; SvRBEC: rat brain endothelial cells; hCMEC/D3: human brain endothelial cells. MFI: Mean Fluorescence Intensity. Since the objective of this experiment was simply to demonstrate cross-reactivity of FC5 with canine endothelial cells as a prerequisite for PK studies, binding across the three cell types was not compared statistically.

Journal: Pharmaceutical Research

Article Title: Pharmacokinetics and Pharmacodynamic Effect of a Blood-Brain Barrier-Crossing Fusion Protein Therapeutic for Alzheimer’s Disease in Rat and Dog

doi: 10.1007/s11095-022-03285-z

Figure Lengend Snippet: FC5 binding to canine, rat and human endothelial cells. Binding studies were carried out as described in Methods section. Bar graph represents data from two independent studies and expressed as mean and range. CnAOEC: Canine (dog) aortic endothelial cells; SvRBEC: rat brain endothelial cells; hCMEC/D3: human brain endothelial cells. MFI: Mean Fluorescence Intensity. Since the objective of this experiment was simply to demonstrate cross-reactivity of FC5 with canine endothelial cells as a prerequisite for PK studies, binding across the three cell types was not compared statistically.

Article Snippet: Immortalized human (HCMEC/D3/HBEC-D3, Dr. Pierre Olivier Couraud, Cochin Institute Université Paris Descartes INSERM, Ref ), rat microvascular brain endothelial cells (sv-ARBEC) and Canine Aortic Endothelial Cells (CnAOEC, Cell Applications Inc., San Diego, CA, USA) were cultured until confluent at 37°C in a humidified 5% CO2 atmosphere in T-75 flasks coated with 100 μg/ml rat tail collagen type 1 (BD Canada, Mississauga, ON, Canada).

Techniques: Binding Assay, Fluorescence